Ethnobiology is a cultural knowledge of living things which include ethnobotany, ethnozoology and ethno ecology. This course covers the nature ethno biological knowledge and the similarities and differences between cultural and traditional knowledge with scientific knowledge. Relationship studies between ethnic groups and interactions with plants, animals and ecological environment is also discussed. Ethno biological research has produced a variety of drugs, natural products, new plants and also provides interesting insights into human cognition, language and behavior management environment from prehistory to today. Thus, the critical issues of contemporary traditional resource conservation, the impact of globalization, and the local people's intellectual property in the global market will also be submitted. Factors influencing the use of plant and animal resources, as well as ethno research in the context of a rapidly changing cultural and environmental will be criticized in a holistic and integrated approach.